Table 3.

Sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of the different methods of fibrosis assessment, with optimal cutoffs based on histological findings^*

Cutoff Se (%) Sp (%) PPV (%) NPV (%)
Metavir fibrosis stage ≥ F2
APRI	1.00	55 50	69 29
FIB-4	0.8	74 60	83 52
FT	0.37	77 80	88 56
FM	0.35	80 70	87 59
FS	7.3	75 85	90 55
Metavir fibrosis stage ≥ F4
APRI	1.2	50 51	23 75
FIB-4	1.05	92 70	46 94
FT	0.5	83 77	50 94
FM	0.68	83 84	58 94
FS	11	71 88	71 88

^*APRI = aspartate transaminase to platelet ratio index; FT = Fibrotest; FM = Fibrometer; FS = Fibroscan.