Table 2.
Comparison of baseline characteristics between patients with and without metabolic syndrome (MS) in combined patient data from FATS, HATS and AFREGS.
| All 3 studies | FATS | HATS | AFREGS | p-value** | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | N | MS (+) | MS (−) | p-value* | MS (+) | MS (−) | MS (+) | MS (−) | MS (+) | MS (−) | |
| Number of patients | n=233 | n=212 | n=60 | n=82 | n=106 | n=54 | n=67 | n=76 | |||
| Age (years), mean±SD | 445 | 55±10 | 53±11 | 0.01 | 48±8 | 45±9 | 54±8 | 52±9 | 64±8 | 63±7 | 0.9 |
| Male Gender | 445 | 88% | 98% | <0.001 | 100% | 100% | 84% | 94% | 85% | 99% | 0.2 |
| BMI (Kg/m2), mean±SD | 445 | 29±4 | 26±3 | <0.001 | 29±4 | 25±3 | 30±4 | 26±3 | 28±4 | 25±3 | 0.4 |
| Clinically established CAD | 303 | 79% | 62% | 0.004 | -- | -- | 83% | 65% | 72% | 59% | 0.4 |
| Prior myocardial infarction | 303 | 47% | 52% | 0.2 | -- | -- | 57% | 52% | 33% | 53% | 0.04 |
| Hypertension | 303 | 72% | 42% | <0.001 | -- | -- | 63% | 20% | 87% | 58% | 0.5 |
| Diabetes mellitus# | 442 | 10% | 1% | <0.001 | 7% | 1% | 18% | 2% | 0% | 0% | 0.6 |
| Current smoking | 302 | 33% | 23% | 0.7 | -- | -- | 50% | 41% | 6% | 11% | 0.2 |
| Total cholesterol (mg/dl), mean±SD |
445 | 217±44 | 224±55 | 0.4 | 265±38 | 274±47 | 198±32 | 194±30 | 203±29 | 190±31 | 0.03 |
| Triglycerides (mg/dl), mean±SD |
444 | 241±107 | 150±83 | <0.001 | 265±135 | 160±96 | 246±103 | 160±80 | 210±77 | 131±65 | 0.08 |
| LDL-C (mg/dl), mean±SD | 445 | 131±42 | 154±52 | <0.001 | 176±42 | 199±49 | 108±27 | 123±33 | 128±27 | 129±26 | 0.2 |
| HDL-C (mg/dl), mean±SD | 445 | 32±5 | 36±8 | <0.001 | 34±4 | 41±9 | 31±5 | 32±4 | 33±5 | 35±6 | 0.12 |
| ApoB (mg/dl), mean±SD | 301 | 131±29 | 139±33 | 0.7 | 156±22 | 156±28 | 116±22 | 114±22 | -- | -- | 0.6 |
| ApoA1 (mg/dl) mean±SD | 301 | 116±16 | 122±20 | 0.7 | 127±13 | 133±16 | 110±15 | 106±13 | -- | -- | 0.005 |
| Fasting glucose (mg/dl) mean±SD |
442 | 99±27 | 85±15 | <0.001 | 98±16 | 89±17 | 108±33 | 91±11 | 87±14 | 77±12 | 0.7 |
| Insulin level (µU/dl) mean±SD |
287 | 24±16 | 16±15 | <0.001 | -- | -- | 27±13 | 18±10 | 18±18 | 14±18 | 0.003 |
| Coronary disease severity, mean %Sprox mean±SD |
415 | 39±12 | 36±12 | 0.003 | 35±12 | 32±12 | 37±11 | 32±9 | 47±10 | 45±8 | 0.4 |
*
Logistic regression of metabolic syndrome, (+) vs.. (−), on the characteristic with adjustment for the study effect
**
P-value for the interaction between the characteristic and study from the logistic regression of metabolic syndrome on the characteristic, the study effect and the interaction between the characteristic and study. This p-value tests whether the difference in characteristics between those with and without metabolic syndrome varies across the three studies.
#
Patients with diabetes at baseline were excluded from FATS.