. Author manuscript; available in PMC: 2011 Feb 1.

Published in final edited form as: J Neural Transm (Vienna). 2009 Dec 10;117(2):227–239. doi: 10.1007/s00702-009-0350-6

Table 3.

Correlations (Pearson's ‘r’) between the pathological features, demographic variables, familial status, and Braak score based on the distribution of neurofibrillary tangles (NFT) and the first three principal components (PC) in various brain regions in cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)

Region	Lesion	PCA-1: all variables			PCA-2: TDP-43 pathology
Region	Lesion
		PC1	PC2	PC3	PC1	PC2	PC3
MFG (U)	NCI	0.06	−0.29^*	−0.16	−0.16	0.02	−0.11
	GI	−0.17	0.05	0.04	−0.01	−0.12	0.12
	NII	−0.05	−0.26	0.07	0.21	0.07	0.39^*
	EN	0.04	−0.13	0.16	−0.02	0.02	−0.08
	N	0.14	−0.55^*	0.06	−0.16	−0.14	0.08
	V	0.46^*	0.25	−0.82^*	−0.08	−0.12	−0.08
	DN	0.07	0.06	0.06	−0.06	−0.62^*	0.32^*
MFG (L)	NCI	0.03	−0.31^*	−0.14	−0.18	0.08	−0.14
	GI	−0.04	−0.06	0.11	−0.11	−0.12	−0.16
	NII	−0.04	−0.31^*	0.10	0.30^*	0.24	0.54^*
	EN	0.18	−0.12	−0.14	−0.08	0.14	−0.14
	N	0.12	−0.34^*	−0.04	−0.08	−0.05	0.14
	V	0.31^*	0.24	−0.67^*	−0.16	−0.17	−0.20
	DN	0.11	0.06	−0.02	0.03	−0.41^*	0.22
ITG (U)	NCI	0.07	−0.20	−0.14	−0.47^*	0.06	−0.49^*
	GI	0.06	0	−0.24	−0.25	0	−0.38^*
	NII	0.02	−0.20	0.06	0.17	0.28^*	0.29^*
	EN	0.07	−0.04	0.04	0.11	−0.02	0.11
	N	0.11	−0.29	−0.06	−0.08	−0.10	−0.05
	V	0.43^*	0.66^*	−0.12	−0.12	−0.34^*	0.05
	DN	0.10	0.14	−0.06	−0.27^*	−0.68^*	0.02
ITG (L)	NCI	−0.05	−0.09	−0.14	−0.26	−0.10	−0.41^*
	GI	−0.03	0.03	0.08	−0.14	−0.22	−0.33^*
	NII	0.13	−0.09	0.10	0.16	0.16	0.48^*
	EN	−0.01	−0.18	−0.16	0.01	0.14	0.02
	N	0.18	−0.22	−0.14	−0.05	−0.10	0.05
	V	0.22	0.57^*	0.10	0	−0.29	0.10
	DN	0.10	0.22	−0.05	−0.10	−0.64^*	0.04
PHG (U)	NCI	−0.08	−0.17	−0.05	−0.51^*	0.19	−0.43^*
	GI	0.05	−0.03	−0.17	−0.18	−0.17	−0.22
	NII	0.15	−0.20	−0.04	0.28^*	0.18	0.40
	EN	0.06	−0.08	−0.04	0.07	0.07	0.08
	N	0.07	−0.29^*	−0.03	−0.02	−0.07	0.13
	V	0.55^*	0.67^*	0.02	0	−0.31^*	0.14
	DN	0.03	0.01	0.14	0.05	−0.44^*	0.14
PHG (L)	NCI	0.09	−0.20	−0.06	−0.27^*	−0.05	−0.34^*
	GI	0.21	−0.11	−0.18	−0.28^*	−0.27	−0.32^*
	NII	0.16	−0.18	0.11	0.12	0.32^*	0.41^*
	EN	−0.01	−0.03	−0.09	0.01	−0.03	0.08
	N	−0.04	−0.46^*	−0.02	−0.02	0.07	0.02
	V	0.57^*	0.54^*	−0.11	0.06	−0.10	0.10
	DN	0.07	0.15	0.18	0.03	−0.40^*	0.07
CA1/2	NCI	−0.07	−0.03	−0.07	−0.08	0.04	−0.39^*
	GI	0.15	−0.20	0.01	−0.05	−0.19	−0.24
	NII	−0.08	−0.11	0.25	0.09	0.38^*	0.44^*
	EN	−0.02	−0.06	0.11	−0.07	−0.15	−0.05
	N	−0.02	−0.24	−0.01	0.03	0.15	−0.13
	V	0.33^*	0.41^*	0.01	0.14	−0.02	−0.16
	DN	0	−0.10	0.03	0.13	−0.29^*	0.04
DG	NCI	0.17	−0.22	−0.11	−0.65^*	0	−0.34^*
	GI	–	–	–	–	–	–
	NII	0.12	−0.04	0.08	0.12	0.14	0.22
	EN	−0.03	0.03	0.03	0	−0.12	−0.07
	N	−0.05	−0.62^*	−0.07	−0.02	0.01	0.09
	V	0	0.64^*	−0.13	0.11	−0.29^*	−0.03
	DN	0.14	0.08	−0.13	−0.16	−0.05	−0.12
Onset		0.06	0.24	0.05	−0.07	−0.01	0.25
Duration		0.28^*	0.09	−0.11	0.09	−0.35^*	0.20
Age at death		0.17	0.26	−0.01	−0.03	−0.19	0.29^*
Brain weight		−0.26	0.04	0.14	−0.06	0.24	0.09
F/S		−0.10	−0.02	0.10	0.30^*	−0.14	0.17
Braak score		−0.06	−0.02	0.10	0.11	−0.17	0.14

All significant correlations, i.e. those significant at P < 0.05 are indicated in bold

Pathological features—NCI neuronal cytoplasmic inclusions, GI oligodendroglial inclusions, NII neuronal intranuclear inclusions, DN dystrophic neurites, EN abnormally enlarged neurons, N surviving neurons, V vacuolation; various brain regions—MFG superior frontal cortex, ITG inferior temporal gyrus, PHG parahippocampal gyrus, CA1/2 sectors CA1 and 2 of the hippocampus, DG dentate gyrus, II/III laminae II/III, V/VI laminae V/VI

P < 0.01