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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Hum Mutat. 2009 Dec;30(12):1611–1619. doi: 10.1002/humu.21120

FIGURE 1.

FIGURE 1

Clinical features of AKU. Detection of excess of homogentisic acid in urine on standing or artificially by adding a base. A: Left panel: Control urine. Left without base added, right with base added. Right panel: AKU urine. Left without base added, right with base added. Three AKU patients with increasing severity (left to right) of clinical symptoms. B: Ochronotic pigmentation of sclerae. C: Auricular cartilages with ochronosis deposition. D: Radiography of dorsolumbar spines: reduction and calcifications of the intervertebral discs (Arrows).