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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Hum Mutat. 2009 Dec;30(12):1611–1619. doi: 10.1002/humu.21120

Table 5.

Predictions of the effect of the 62 identified missense variations on HGD protein function a

Study SIFT SNAP POLYPHEN PANTHER PMUT Common b
Deleterious 33 33 32 24 21 17
Ambiguous 1 0 3 0 0 0
Benign 2 3 1 12 15 0
Published SIFT SNAP POLYPHEN PANTHER PMUT Common b
Deleterious 22 22 18 15 14 12
Ambiguous 0 0 5 0 0 0
Benign 4 4 3 11 12 2
a

The predictions were made using prediction software (SIFT, POLYPHEN, PANTHER, PMUT and SNAP), see Supporting Information for more details

b

Number of variants that have the same prediction in all the prediction tools