Figure 2.

Intrathecal administration of rapamycin attenuates mechanical hyperalgesia in the SNI model. Effect of intrathecal injection of rapamycin, or its vehicle on, A, mechanical withdrawal threshold measured with Von Frey hairs, and B, withdrawal response duration (s) after nociceptive mechanical stimulation (pinprick stimulus) of the lateral plantar surface of the paw of SNI animals, or sham animals. Mean ± SEM is illustrated. N = 3–4 in sham groups, N = 7–8 in SNI groups. *p < 0.05, ***p < 0.001.