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. 2010 Mar;24(3):653–664. doi: 10.1096/fj.09-132456

TABLE 2.

Ca2+-binding properties of chromogranins/secretogranin II and their respective concentrations in the ER and secretory granules of bovine chromaffin cells

Protein Ca2+ binding (mol/mol protein) Kd (mM) Concentration (μM)
Endoplasmic reticulum Secretory granule
Chromogranin A 32–55 2.7–4.0 >140 >1800
Chromogranin B 50–93 1.5–3.1 >120 >200
Secretogranin II 30–61 2.2–3.0 >10 >30

Ca2+-binding and Kd values from refs. 35 (chromogranin A), 34, 36 (chromogranin B), and 36 (secretogranin II). Concentration values from refs. 28, 36.