TABLE 1.
Hematological analysis of both arms of the study
| Parameter | Time (min)
|
|||||
|---|---|---|---|---|---|---|
| 0 | 30 | 60 | 120 | 180 | 240 | |
| E. coli | ||||||
| Hb (g/L)* | ||||||
| Positive control | 7.8 (7.4–8.3) | 7.9 (7.4–8.4) | 7.9 (7.4–8.4) | 8.5 (8.0–9.0) | 8.9 (8.4–9.4) | 9.0 (8.3–9.7) |
| aCD14 | 7.5 (6.5–8.4) | 8.0 (7.0–9.0) | 7.9 (6.9–8.9) | 7.7 (6.8–8.6) | 8.0 (7.0–8.9) | 8.2 (7.2–9.2) |
| Negative control | 8.5 (7.3–9.6) | 8.1 (7.1–9.1) | 8.0 (6.9–9.0) | 8.0 (7.0–9.0) | 8.0 (7.0–9.0) | 8.3 (7.3–9.2) |
| WBC (×109/L)* | ||||||
| Positive control | 15.3 (12.6–18) | 13.6 (11.5–15.6) | 10.8 (8.8–12.8) | 8.3 (5.4–11.1) | 7.1 (3.8–10.4) | 7.5 (4.7–10.3) |
| aCD14 | 17.3 (13.4–21.2) | 23.0 (14.7–31.3) | 23.8 (14.9–32.8) | 19.6 (12.5–26.8) | 13.9 (9.6–18.2) | 21.5 (11.5–31.4) |
| Negative control | 19.2 (15.3–23.1) | 16.3 (12.2–20.4) | 15.4 (10.0–20.7) | 16.1 (10.6–21.6) | 15.9 (10.9–20.9) | 18.0 (13.1–22.9) |
| Neutrophils (×109/L)* | ||||||
| Positive control | 6.2 (4.0–8.3) | 6.3 (4.5–8.0) | 4.6 (3.2–6.0) | 4.4 (1.9–6.9) | 3.9 (0.9–6.9) | 4.4 (2.0–6.9) |
| aCD14 | 7.6 (5.1–10.2) | 14.7 (8.3–21.0) | 17.0 (9.7–24.3) | 14.3 (8.3–20.3) | 10.4 (6.6–14.1) | 18.0 (8.9–27.0) |
| Negative control | 8.8 (5.1–12.4) | 8.7 (5.1–12.2) | 8.5 (3.0–14.0) | 9.6 (3.6–15.6) | 9.8 (4.9–14.6) | 11.3 (6.2–16.3) |
| LPS | ||||||
| Hb (g/L) | ||||||
| Positive control | 7.6 (6.8–8.1) | 9.3 (8.1–10.4) | 8.2 (7.1–8.9) | 8.7 (7.6–9.3) | 9.4 (7.8–10.5) | 9.5 (7.9–10.3) |
| aCD14 | 7.9 (7.6–8.5) | 9.0 (8.4–9.9) | 9.0 (8.5–10.3) | 9.0 (8.5–10.8) | 9.1 (8.3–10.8) | 8.6 (7.2–10.1) |
| WBC (×109/L) | ||||||
| Positive control | 18.1 (13.4–23.5) | 9.7 (7.3–13.7) | 5.6 (3.8–8.6) | 4.1 (2.4–7.3) | 5.9 (3.1–11.3) | 6.8 (3.7–12.9) |
| aCD14 | 16.3 (12.2–21.1) | 19.5 (14.2–22.9) | 11.0 (7.2–18.4) | 12.2 (10.6–14.2) | 16.5 (14.0–21.3) | 17.6 (13.0–22.6) |
| Neutrophils (×109/L) | ||||||
| Positive control | 8.0 (4.9–13.2) | 5.4 (3.4–9.3) | 2.0 (0.9–3.4) | 1.6 (0.2–4.0) | 3.4 (0.9–7.9) | 4.3 (1.3–9.5) |
| aCD14 | 6.2 (3.5–8.9) | 11.0 (4.9–15.3) | 5.6 (2.3–10.3) | 7.6 (6.1–9.3) | 11.9 (9.5–15.8) | 13.3 |
Data in the E. coli arm are presented as mean and 95% CI; data in the LPS arm are presented as mean and range.
*
P < 0.05 for anti-CD14 vs. positive control group.