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. 2010 Feb 16;10:43. doi: 10.1186/1471-2407-10-43

Figure 3.

Figure 3

Interruption of BDNF-induced cell invasion by TrkB-siRNA. In TrkB-siRNA transfected A549 cells, the decreased activity of Pyk2 in Tyr402 promoted by BDNF was detected, which was much lower than that in non-silencing siRNA transfected and control cells. The activation of ERK was also attenuated after TrkB silencing (A). The invasion of TrkB-siRNA transfected A549 cells was greatly inhibited, in comparison to those non-silencing and control cells (B). Original magnification, all ×400. The data are representative of three individual experiments.