Table 1.
Baseline Indicators of Depressed Adolescents with and without ADHD
| TADS youth with ADHD n = 62 | Without ADHD n = 377 | p value | ||
|---|---|---|---|---|
| Gender (male) | n (%) | 41 (66.13%) | 159 (42.18%) | <0.005 |
| Caucasian | n (%) | 50 (80.65%) | 274 (72.68%) | 0.214 |
| Initial depressive episode | n (%) | 50 (81.97%) | 319 (86.68%) | 0.322 |
| Depression severity (CDRS-R total) | Mean (SD) | 57.58 (9.87) | 60.52 (10.43) | 0.030 |
| Adolescent-reported MDD (RADS total) | Mean (SD) | 74.46 (12.61) | 80.01 (14.48) | 0.003 |
| Global functioning (CGAS rating) | Mean (SD) | 50.05 (7.70) | 49.57 (07.44) | 0.690 |
| Potential risk of suicidality flag (SIQ-Jr) | n (%) | 14 (23.73%) | 111 (30.08%) | 0.358 |
| Current dysthymia disorder | n (%) | 11 (17.74%) | 35 (9.31%) | 0.070 |
| Current anxiety disorder | n (%) | 12 (19.35%) | 108 (28.72%) | 0.166 |
| Current oppositional defiant disorder | n (%) | 18 (29.03%) | 40 (10.61%) | <0.001 |
| Current substance abuse disorder | n (%) | 1 (1.61%) | 6 (1.59%) | 1.000 |
| Current alcohol abuse disorder | n (%) | 1 (1.61%) | 2 (0.53%) | 0.358 |
Table's values are expressed as n = number of randomized participants (percentage [%]), or as a group mean (standard deviation [SD]). For mean data, p values represent the Fisher exact tests for binary measures and Student t-tests for continuous measures.
Anxiety disorder includes the diagnoses of panic disorder, separation anxiety disorder, specific phobia, social phobia, agoraphobia, generalized anxiety disorder, posttraumatic stress disorder, and/or acute stress disorder.
Abbreviations: ADHD = Attention-deficit/hyperactivity disorder; TADS = Treatment for Adolescents with Depression Study; CDRS-R = Children's Depression Rating Scale–Revised; MDD = major depressive disorder; RADS = Reynolds Adolescent Depression Scale; SIQ-Jr = Suicidal Inventory Questionnaire–Junior High School Version.