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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: J Immunol. 2004 Dec 1;173(11):7003–7009. doi: 10.4049/jimmunol.173.11.7003

FIGURE 4.

FIGURE 4

Assessment of airways hyperresponsiveness following allergen sensitization and challenge. Pulmonary hyperresponsiveness was analyzed in mock-sensitized (Alum/OVA, open symbols and broken lines) or OVA-sensitized (OVA/OVA, filled symbols and solid lines) CC10-IκBαsr (Tg, squares) or transgene negative littermate control (WT, circles) mice 48 h following the third daily aerosolized OVA challenge. Hyperresponsiveness to ascending doses of nebulized methacholine was assessed from forced oscillations and determined as Rn (airway resistance, A) and H (tissue elastance, B). As derived from the constant phase model, data are expressed as the percent change from baseline measurements (± SEM) for each of the parameters measured, are inclusive of results from three separate experiments, and comprised of 11–13 mice per group. Baseline measurements before methacholine were found not to be significantly different between any of the groups (data not shown).