FIG. 4. .

Basal intestinal transepithelial resistance (TER; Ω·cm²) in jejunum. Control (□), total parenteral nutrition (TPN; Δ), and TPN–glutamine (▾) study groups. Results are represented as mean ± SD. Time 0 represents the time at which all tissues were mounted in Ussing chambers following a 30-min equilibration period to achieve steady-state conditions. At all time points, TER in the TPN group was significantly (P < 0.05) lower than in the control group. The loss of TER for TPN mice was significantly ameliorated with glutamine administration; however, TER values did not return to the level of control mice. N = 6 per group. Not shown (because of the overlapping of lines) was that the blockade with anti-IL-7R antibody administration in TPN mice failed to impact TER.