Rats that received vehicle 48 hrs post-MCAO exhibited a robust neuroinflammatory response at 72 hrs. Cells displaying CD11b immunoreactivity (A) and isolectin-tagged fluorescence (D) infiltrated the striatal infarct in greater quantities relative to the 51 hr timepoint. Isolectin-binding colocalized to many CD11b-positive, amoeboid shaped immune cells (B,E). Both CD11b-expressing (C) and isolectin-binding (F) cells were also greatly elevated in peri-infarct tissues adjacent to the corpus callosum. Scale bars: A,C,D,F = 100 μm; B,E = 50 μm. CC = corpus callosum.