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Specific dopamine receptor antagonists inhibit the growth-promoting effects of dopamine. Mz-ChA-1 cells were pretreated with specific antagonists of the dopamine receptors indicated (all at 10 nM), prior to the addition of dopamine (100 nM) for 48 hr. Cell proliferation was assessed using an MTS cell proliferation assay. Data are expressed as fold change in proliferation (average ± SEM, n=7) and the asterisk denotes p<0.05 compared to antagonist alone.
