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. Author manuscript; available in PMC: 2011 May 1.

Published in final edited form as: Int J Cancer. 2010 May 1;126(9):2112–2122. doi: 10.1002/ijc.24909

Inhibition of dopamine synthesis decreases tumor growth in an in vivo xenograft model of cholangiocarcinoma. Mz-ChA-1 cells were injected into the flank of athymic mice. After tumors were established, mice were treated with 100 mg/kg/day (ip) α-methyl dopa, three days per week for 70 days and tumor volume assessed (A). Tumor latency was assessed as the time taken for the tumor to grow to 150% of the original size (B). Data are expressed as average latency (days ± SEM) and the asterisk denotes significance (p<0.05) from vehicle-treated tumors.

Inhibition of dopamine synthesis decreases tumor growth in an in vivo xenograft model of cholangiocarcinoma. Mz-ChA-1 cells were injected into the flank of athymic mice. After tumors were established, mice were treated with 100 mg/kg/day (ip) α-methyl dopa, three days per week for 70 days and tumor volume assessed (A). Tumor latency was assessed as the time taken for the tumor to grow to 150% of the original size (B). Data are expressed as average latency (days ± SEM) and the asterisk denotes significance (p<0.05) from vehicle-treated tumors.