Table 5.

Factors Influencing Discontinuation of Cyclosporine

Characteristic Name		Crude RR Discontinuation Due to Side Effects, RR (95% CI)	Adjusted RR Discontinuation Due to Side Effects, RR (95% CI)
Age	Less than 18 years	0.88 (0.31 - 2.47)	0.80 (0.29 - 2.23)
Age	18-39 years	1.00	1.00
Age	40-54 years	1.81 (1.00 - 3.28)	1.69 (0.90 - 3.18)
Age	55-64 years	3.35 (1.63 - 6.88)	3.25 (1.54 - 6.88)
Age	65 years or more	4.43 (2.09 - 9.36)	5.66 (2.14 - 14.98)
Type of inflammation	Anterior	1.00	1.00
Type of inflammation	Intermediate	0.39 (0.18 - 0.83)	0.49 (0.22 - 1.09)
Type of inflammation	Posterior/Panuveitis	0.68 (0.38 - 1.21)	0.73 (0.38 - 1.42)
Type of inflammation	Scleritis	2.30 (0.93 - 5.67)	2.01 (0.55 - 7.40)
Type of inflammation	Mucous Membrane Pemphigoid	0.90 (0.14 - 5.75)	0.41 (0.05 - 3.36)
Dosage	150 mg/day or less	1.00	1.00
Dosage	151-250 mg/day	0.34 (0.17 - 0.69)	0.34 (0.16 - 0.73)
Dosage	251-350 mg/day	0.53 (0.27 - 1.04)	0.59 (0.29 - 1.20)
Dosage	351 mg/day or more	0.55 (0.30 - 1.03)	0.69 (0.35 - 1.34)
Systemic (extraocular) autoimmune disease	Yes	0.98 (0.60 - 1.62)	0.76 (0.42 - 1.39)

RR=Relative risk

CI=Confidence interval