Table 1. Monogenic or single gene disorders causing stroke, classified according to the each one's stroke subtype.

Stroke Subtype	Specific Monogenic Disease
Small vessel disease	CADASIL
	CARASIL
	Cerebrovascular retinopathy and HERNS
	COL4A1 small vessel arteriopathy with haemorrhage
Large artery atherosclerosis and other arteriopathies	Familial hyperlipidaemias
	Moya-Moya disease
	Pseudoxanthoma elasticum
	Neurofibromatosis type I
Large artery disease—dissection	Ehlers-Danlos syndrome type IV
	Marfan syndrome
	Fibromuscular dysplasia
Disorders affecting both small and large arteries	Fabry disease
	Homocysteinuria
	Sickle cell disease
Cardioembolism	Familial cardiomyopathies
	Familial arrhythmias
	Hereditary haemorrhagic telangiectasia
Prothrombotic disorders
Mitochondrial disorders	MELAS

HERNS, hereditary endotheliopathy with retinopathy, nephropathy, and stroke; MELAS, Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke.