Figure 3. Effects of tribendimidine on Heligmosomoides bakeri infections in mice.

Shown are the intestinal worm burdens in placebo (20 mM citrate buffer pH 7.3) and for various doses of tribendimidine. Data are plotted as in Figure 1. Infected mice (n = 6/group except n = 5 placebo) were given a single dose of tribendimidine on day 15 P.I. and intestinal worm burdens assessed on day 20 P.I. **P<0.01, ***P<0.001 relative to placebo control. Conversion to molar amounts is as follows: 0.125, 0.5, and 2 mg/kg are equivalent to 0.28, 1.1, and 4.4 µmoles/kg respectively.