Figure 5. Visualization of the reciprocal coupling pairs for Pak2, PKA and Src.

(a) Four common reciprocal coupling pairs for Pak2 were superimposed on the Pak1 structure (1YHV.PDB) (see Table 1). (b) Five specific reciprocal coupling pairs were superimposed on the same structure. (c) Four specific reciprocal coupling pairs for PKA were identified on the PKA structure (1ATP.PDB). (d) Two specific reciprocal coupling pairs in Src were shown on 2SRC.PDB. The same color was used when two residues were reciprocally coupled. In (c) and (d), the common reciprocal couplings between the three structures are in gray.