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Zymogen activation is observed in both a zymogen granule-enriched (ZG) and microsomal (Mic) fraction following supraphysiological caerulein treatment in vivo. Rats were treated for 15 min with caerulein (40 μg/kg body wt) via tail vein injection. Enhanced trypsin (A) and chymotrypsin (B) activities are seen in both ZG and Mic fractions at 15 min. *P < 0.05 vs. ZG or Mic from unstimulated pancreas (control).
