Table 4. Effects of proteasome inhibitors on chymotrypsinogen activation.
Condition | ZG | ZG/Cyt | ZG/Cyt/ATP | Mic | Mic/Cyt | Mic/Cyt/ATP |
---|---|---|---|---|---|---|
Chymotrypsin activity | ||||||
Control | 0 | 37±10 | 100 | 0 | 44±5 | 100 |
Lactacystin | 0 | 48±4 | 130 ± 7* | 0 | 43±6 | 123 ± 2* |
Chymotrypsin activity | ||||||
Control | 0 | 28±2 | 100 | 0 | 44±5 | 100 |
MG-132 | 0 | 38±7 | 121 ± 4 | 0 | 46±4 | 118 ± 9 |
Values are means of %activity ± SE. For ZG data, maximal activity (100%) is set as ZG/Cyt/ATP control. For Mic data, maximal activity (100%) is set as Mic/Cyt/ATP control. Comparison of like conditions show no significant differences except where indicated. *P < 0.05. It is interesting to note that these significant differences do not refer to an inhibitory event.