Table 3.

Hazard Ratio (HR) of Rev/IMT for MI, Cardiac Death, and Cardiac Death or MI within Glycemic Randomization Arm

	MI			Cardiac Death			Cardiac Death/MI
	5 Year KM Estimate	HR Rev/IMT (95% CI)	Nominal p-value for HR	5 Year KM Estimate	HR Rev/IMT (95% CI)	Nominal p-value for HR	5 Year KM Estimate	HR Rev/IMT (95% CI)	Nominal p-value for HR
All Patients (n = 2368)
Insulin Sensitization
Rev(n= 584)	10.3% (56)	0.78 (0.55–1.10)	0.16	5.5% (34)	1.11 (0.68–1.80)	0.68	14.2% (79)	0.92 (0.68–1.24)	0.57
IMT(n=599)	14.1% (74)			5.8% (32)			16.9% (89)
Insulin Provision
Rev(n= 592)	12.7% (72)	0.97 (0.70–1.34)	0.85	6.4% (38)	1.21 (0.76–1.94)	0.42	17.6% (99)	1.15 (0.86–1.52)	0.35
IMT(n=593)	14.4% (77)			5.7% (32)			16.5% (90)
PCI stratum (n=1605)
Insulin Sensitization
Rev(n=396)	12.1% (45)	1.18 (0.77–1.80)	0.45	5.0% (23)	1.74 (0.89–3.38)	0.10	15.7% (61)	1.39 (0.95–2.03)	0.09
IMT(n=408)	11.7% (41)			3.7% (14)			13.3% (47)
Insulin Provision
Rev(n= 402)	12.4% (50)	1.08 (0.73–1.62)	0.69	5.0% (21)	1.12 (0.60–2.07)	0.73	16.3% (65)	1.23 (0.86–1.76)	0.26
IMT(n=399)	13.5% (47)			4.8% (19)			15.2% (54)
CABG stratum (n =763)
Insulin Sensitization
Rev(n=188)	6.3% (11)	0.32 (0.16–0.64)	0.001**	6.6% (11)	0.62 (0.29–1.32)	0.21	11.0% (18)	0.41 (0.24–0.72)	0.002**
IMT(n=191)	19.0% (33)			10.5% (18)			24.6%(42)
Insulin Provision
Rev(n= 190)	13.5% (22)	0.79 (0.45–1.37)	0.40	9.4% (17)	1.37 (0.67–2.83)	0.39	20.5% (34)	1.03 (0.64–1.64)	0.91
IMT(n=194)	16.2% (30)			7.6% (13)			19.3% (36)

CABG = coronary artery bypass grafting; MI = myocardial infarction; PCI = percutaneous coronary intervention; Rev/Med = revascularization/medicine;

Kaplan-Meier values are expressed as percentage (n). CI indicates confidence interal.

^**significant after Bonferroni adjustment for multiple tests done in the table