Table 4.
Parameters fitted to the pharmacodynamic model
| Parameter | Parameter estimate | % RSE for parameter | ω Estimate | % RSE for ω estimate |
|---|---|---|---|---|
| E0 (AU) | 0.544 | 4.17 | 0.019 | 41.2 |
| Emax,caps (AU) | 2.56 | 18.4 | 0.257 | 49.8 |
| Emax,CGRP (fraction) | 0.921 | 2.76 | NA | NA |
| ED50, caps (µg per 20 µl) | 430 | 46.5 | 3.57 | 44.5 |
| EC50, telcagepant | 101 | 37.3 | NA | NA |
| ΔE0, pilot | 0.416 | 11.2 | NA | NA |
| ΔE0, telcagepant | −0.115 | 21.8 | NA | NA |
| Proportional residual error | 0.0678 | 10.5 |
AU, arbitrary units; RSE, relative standard error. See text for definition of parameters.