Table 1.
Geometric mean (%CV) pharmacokinetic parameters and statistical analyses for maraviroc
| Parameters (units) | Maraviroc alone | Maraviroc + raltegravir | % Ratio (95% CI)* |
|---|---|---|---|
| AUCτ (ng h−1 ml−1) | 2853 (28%) | 2447 (31%) | 85.8 (78.7, 93.5) |
| Cmax (ng ml−1) | 785 (41%) | 624 (47%) | 79.5 (64.8, 97.5) |
| Cmin (ng ml−1) | 51.6 (26%) | 46.6 (28%) | 90.3 (84.2, 96.9) |
| Tmax (h)† | 2.0 (0.5–4.0) | 2.0 (0.5–4.0) | NA‡ |
*
Ratio based on adjusted geometric means for combination treatment vs. single agent obtained from anova model.
†
Median (range).
‡
NA, not applicable.