Table 2.
Geometric mean (%CV) pharmacokinetic parameters and statistical analyses for raltegravir
| Parameters (units) | Raltegravir alone | Maraviroc + raltegravir | % Ratio (95% CI)* |
|---|---|---|---|
| AUCτ (ng h−1 ml−1) | 7356 (58) | 4819 (63) | 63.3 (41.0, 97.6) |
| Cmax (ng ml−1) | 2116 (67) | 1486 (72) | 66.8 (37.1, 120.0) |
| Cmin (ng ml−1) | 66.2 (49) | 47.0 (44) | 72.4 (55.1, 95.2) |
| Tmax (h)† | 2.5 (1.0–6.0) | 1.0 (0.0–2.0) | NA‡ |
*
Ratio based on adjusted geometric means for combination treatment vs. single agent obtained from anova model.
†
Median (range).
‡
NA, not applicable.