Table 3.
The 10 most suspicious drug–drug–adverse drug reaction (ADR) combinations detected by logistic regression in the database-wide screen
| Drug combinations (A and B) | ADR | n | OR (drug A) | OR (drug B) | OR (A and B) | |
|---|---|---|---|---|---|---|
| Levodopa and benserazide | Amantadine | Ataxia | 4 | 117.66 (30.04–460.91) | 0 (0–∞) | >999.99 (>999.99–>999.99) |
| Interferon alfa-2a | Ribavirin | Thyroid disorder | 21 | 769.16 (317.54–>999.99) | 0 (0–∞) | >999.99 (898.54–>999.99) |
| Mycophenolate mofetil | Prednisone | Abnormal lung function | 6 | 114.77 (32.23–408.68) | 0 (0–∞) | >999.99 (491.66–>999.99) |
| Chlorpromazine | Risperidone | Extrapyramidal disorder | 5 | 200.62 (125.72–320.15) | 202.48 (137.27–298.65) | 904.65 (172.24–>999.99) |
| Glucophage | Gliclazide | Hypoglycaemia | 3 | 5.63 (0.76–41.45) | 0 (0–∞) | 647.83 (101.91–>999.99) |
| Mycophenolate mofetil | Ciclosporin | Constipation | 4 | 0 (0–∞) | 0 (0–∞) | 257.25 (62.71–>999.99) |
| Interferon alfa-2a | Ribavirin | Marrow suppression | 33 | 53.30 (34.57–82.20) | 0 (0–∞) | 156.95 (93.41–263.72) |
| Azithromycin | Fleroxacin | Sleep disorder | 5 | 0.32 (0.08–1.27) | 11.56 (7.16–18.67) | 87.93 (30.77–251.27) |
| Capecitabine | Oxaliplatin | Thrombocytopenia | 4 | 0 (0–∞) | 0 (0–∞) | 45.03 (15.34–132.19) |
| Mezlocillin | Penicillin sodium | Allergic reaction | 7 | 0.76 (0.28−2.08) | 1.88 (1.46−2.41) | 4.33 (1.86−10.05) |