Table 4.

The 10 most suspicious drug–drug–adverse drug reaction (ADR) combinations detected by the Ω shrinkage measure method

Drug combinations (A and B)		ADR	n	Ω025
Mycophenolate mofetil	Ciclosporin	Constipation	4	1.69
Capecitabine	Oxaliplatin	Thrombocytopenia	4	1.56
Levodopa and benserazide	Benzhexol	Neurosis	6	1.50
Methotrexate	Dexamethasone	Muscle weakness	7	1.34
Levodopa and benserazide	Amantadine	Ataxia	4	1.18
Mycophenolate mofetil	Prednisone	Abnormal lung function	6	0.80
Glucophage	Gliclazide	Hypoglycaemia	3	0.66
Interferon alfa-2a	Ribavirin	Thyroid disorder	21	0.74
Tarceva	Gemcitabine	Diarrhoea	5	0.50
Azithromycin	Fleroxacin	Sleep disorder	5	0.42