Table 5.

The 10 most suspicious drug–drug–adverse drug reaction (ADR) combinations detected by the additive and multiplicative model

Drug combinations (A and B)		Adverse drug reaction	n	δ1	P1	δ2	P2
Levodopa and benserazide	Amantadine	Ataxia	4	0.8	<0.001	*	<0.001
Levodopa and benserazide	Benzhexol	Neurosis	6	0.78	<0.001	*	<0.001
Tarceva	Gemcitabine	Diarrhoea	5	0.66	<0.001	6.91	<0.001
Mycophenolate mofetil	Ciclosporin	Constipation	4	0.5	0.005	*	<0.001
Interferon alfa-2a	Ribavirin	Marrow suppression	33	0.27	<0.001	3.52	<0.001
Interferon alfa-2a	Ribavirin	Thyroid disorder	21	0.21	<0.001	*	<0.001
Azithromycin	Fleroxacin	Sleep disorder	5	0.21	0.011	21.22	<0.001
Cefuroxime	Clindamycin	Local swelling	4	0.21	0.027	13.44	<0.001
Mezlocillin	Penicillin sodium	Allergic reaction	7	0.15	0.029	3.98	<0.001
Interferon alfa-2a	Ribavirin	Leucopenia	17	0.12	<0.001	1.67	<0.001

δ₁ and P₁ represent the result of the additive model and δ₂ and P₂ represent the result of the multiplicative model. The meaning of

^*is as in Table 2.