Table 3.
Cases occurring in the first year of follow-up and their controls | Cases occurring after 1 year's follow-up and their controls | |||
---|---|---|---|---|
Cases | Controls | Cases | Controls | |
Numbers | 4720 | 70 634 | 6878 | 102 151 |
Age (continuous) (years)† | 66 (±9) | 66 (±9) | 67 (±9) | 67 (±9) |
Statin adherence (%)‡ | ||||
1–19 (%) | 0.2 | 0.1 | 0.1 | 0.1 |
20–39 (%) | 2 | 1 | 2 | 2 |
40–59 (%) | 3 | 3 | 5 | 4 |
60–79 (%) | 7.2 | 6.6 | 11 | 10 |
≥80 (%) | 88 | 89 | 82 | 83 |
Sex (% male)† | 43 | 37 | 40 | 33 |
Social assistance (%)† | 12 | 10 | 12 | 10 |
Cerebrovascular disease during follow-up (%)§ | 2 | 1 | 4 | 2 |
Chronic heart failure during follow-up (%)¶ | 2 | 0.4 | 4 | 1 |
Peripheral arterial disease during follow-up (%)†† | 1.7 | 0.4 | 3.0 | 1.6 |
Other cardiovascular events during follow-up (%)‡‡ | 12 | 2 | 17 | 7 |
Having ≥2 cardiovascular events (%) | 4 | 0.3 | 9 | 2 |
Diabetes (%)§§ | 13 | 10 | 19 | 16 |
Diagnosed and nontreated (%)§§ | 4 | 3 | 7 | 6 |
Newly treated for diabetes mellitus (%)§§ | 4 | 3 | 2 | 1 |
Antidiabetic agents adherence <80% (%)§§¶¶ | 1.4 | 0.9 | 3 | 2 |
Antidiabetic agent adherence ≥80% (%)§§¶¶ | 4 | 3 | 8 | 7 |
Dyslipidaemia (%)§§ | 29 | 24 | 40 | 34 |
Diagnosed and nontreated (%)§§ | 3 | 3 | 4 | 4 |
Newly treated for dyslipidaemia (%)§§ | 15 | 10 | 8 | 5 |
Lipid-lowering agent adherence <80% (%)§§¶¶ | 3 | 3 | 9 | 7 |
Lipid-lowering agent adherence ≥80% (%)§§¶¶ | 8 | 9 | 19 | 18 |
Respiratory diseases (%)§§ | 16 | 11 | 25 | 17 |
Antidepressant drugs (%)§§ | 9 | 8 | 15 | 12 |
Anxiolytic drugs (%)§§ | 32 | 28 | 42 | 36 |
Chronic disease score (≥4) (%) | 11 | 8 | 14 | 10 |
At treatment initiation.
Proportion of days covered (%).
Diagnosis of cerebrovascular disease (ICD-9 codes 430–438) or medical procedures.
Diagnosis of chronic heart failure (ICD-9 codes 398.91, 402.01, 402.11, 402.91, 428.0, 428.1 and 428.9) or a prescription of furosemide alone or with digoxin, angiotensin converting enzyme inhibitors, spironolactone or β-blockers.
Diagnosis of peripheral arterial disease: diagnosis (ICD-9 codes 440–447, medical procedure of noncoronary angioplasty, or use of pentoxifylline).
Diagnosis of other cardiovascular disease: arrhythmia: diagnosis (ICD-9 code 427), a medical procedure using a pacemaker and the use of drugs for cardiac arrhythmias (amiodarone, digoxin, quinidine, disopyramide, flecainamide, mexiletine, procainamide, propafenone, or sotalol); or valvular heart disease; or anticoagulants; other cardiopathy.
ICD-9 or pharmacological treatment.
Proportion of days covered (%) in the year before the index date.