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. Author manuscript; available in PMC: 2011 Mar 19.
Published in final edited form as: J Mol Biol. 2010 Jan 15;397(1):278–289. doi: 10.1016/j.jmb.2010.01.017

Figure 7.

Figure 7

Elf3 binding to the TβR-II promoter. (A) A cartoon representation of the model of Elf3 bound to the A- and B-sites of the TβR-II promoter. The DNA fragment shared by both Elf3 molecules is marked by dashed lines (B) A schematic representation of the two-step mechanism of Elf3 binding to the TβR-II promoter. The first Elf3 molecule binds to the high-affinity B-site and induces conformational changes in the A-site (dashed lines). The conformational changes in the A-site allow binding of a second Elf3 molecule to the major groove of the A-site.