Table 4.
Genetic factors predisposing to infections in systemic lupus erythematosus.
| Gene | Chromosome | SNP | Infection | Ref. |
|---|---|---|---|---|
| Mannose-binding lectin deficiency |
10 |
Alleles B,C,D Codons 54,57,52 |
Staphylococcus aureus Pseudomonas aeruginosa Community-acquired pneumonia (Streptococcus pneumoniae, Haemophilus influenzae, Legionella, Mycoplasma pneumoniae) Invasive aspergillosis Influenza A and B Herpes simplex virus 1 and 2 |
[14,15,75,76] |
| C1q deficiency |
– |
rs631090 rs292001 rs294183 |
Recurrent bacterial infections Otitis media Meningitis Pneumonia |
[77] |
|
IRF5 |
7q32 |
rs2004640 |
Paramyxovirus (Newcastle disease virus) Other viral infections |
[79,80] |
|
STAT4 |
2 |
rs7574865 |
Pseudomonas |
[86] |
| ITGAM | 16 | rs1143679 | – | [84] |