Figure 4.

Integrin leg domains. Domains in α_Xβ₂ are coloured as in Figure 2A and B and in other integrins are silver with dashes for disordered loops and metals as spheres. (A) The genus. (B) The α_X and α_IIb thigh and calf-1 domains superimposed on calf-1. (C) The α_X and α_IIb calf-1 and calf-2 domains superimposed on calf-2. (D) The β₂ and β₃ (Zhu et al, 2008) legs superimposed on I-EGF domains 2–4. (E) Bent intact β₂-leg and β₂-leg fragment (Shi et al, 2007) superimposed on I-EGF2. (F) Superimposed β₂ and β₃ (Xiong et al, 2001)-tail domains.