Table.

Potential Treatments for Functional GI Disorders in Children

Functional Disorder	Medication	Dose	Level of Evidence	Key Points
IBS	Amitriptyline	10 mg (30-50 kg); 20 mg (50-80 kg); 30 mg (>80 kg); Taken at bedtime	RCT in adolescents	Need screening EKG
IBS	Peppermint Oil	374 mg TID (>45 kg); 187 mg TID (30-45 kg)	Small RCT	2-week trial to determine benefit
IBS	Lactobacillus GG	3×109 Colony Forming Units twice daily	Small RCT	Small sample size and wide confidence intervals in RCT
FAP	Citalopram	Initial 10 mg; 2nd week 20 mg; 4th week 40 mg; Daily dosing	Open-labeled, prospective, non-controlled pediatric trial	May stop increasing dose at minimum effective or tolerated dose
FD	Famotidine	0.5 mg/kg/dose twice daily	Double blind, placebo controlled, crossover trial	Maximum daily dose of 40 mg
FD	Montelukast	10 mg daily	Double blind, placebo-controlled, crossover trial	Effective in patients with eosinophilia on duodenal biopsies
FD with delayed gastric emptying	Erythromycin	3-5 mg/kg three to four times daily	Empiric	1-week trial to determine symptomatic relief