Figure 6.

Reduced ischemic injury in the absence of CD36. Ischemic outcome in ApoE KO and ApoE/CD36 DKO mice fed HD for 8 weeks. A, B, Infarct volume (A) and percentage swelling (B) were determined 3 d after ischemia. C, Correlation analysis between infarct volume and percentage swelling shows that a disproportionately larger contribution of the swelling component in ApoE KO mice was reduced in DKO mice. D–F, Between ApoE KO and DKO mice, cholesterol levels before ischemia (D), plasma MCP-1 levels (in picograms per milliliter) 3 d after ischemia (E), and MCP-1 gene expression from macrophages 3 d after ischemia (F) were comparable. **p < 0.01, and ***p < 0.001 versus ApoE KO.