Figure 7.

Reduced ischemia-induced proinflammatory cytokines and chemokine gene expression in the CD36-deficient brain. A–F, mRNA levels for proinflammatory MCP-1 (A), CCR2 (B), TNF-α (C), IL-1β (D), IL-6 (E), and anti-inflammatory IL-13 (F) were measured at 6 h after ischemia. Proinflammatory chemokine and cytokine gene expression was reduced in the absence of cd36. WT, Normal-diet-fed wild type; ApoE KO, high-fat-fed ApoE KO; DKO, high-fat-fed ApoE/CD36 double KO. n = 4–5 per group. *p < 0.05 versus contralateral; ^#p < 0.05 versus ApoE KO ipsilateral.