Figure 8.

Reduced foam cell formation in the brain and macrophages in the absence of cd36. A, Oil Red-O-stained foam cells in the brain 3 d after ischemia. Sections are at the level of striatum (+1.6 mm from bregma) from hyperlipidemic ApoE KO and DKO mice. The DKO photomicrographs in the top were taken from the DKO brain that exhibited the most foam cells. Numerous foam cells were present in the penumbra of ApoE KO mice, whereas the majority of DKO mice were devoid of foam cells. Arrows indicate cells in insets from which high-power photomicrographs were taken. B, oxLDL-induced foam cell formation in mouse peritoneal macrophages obtained from KO and DKO mice fed 8 weeks of HD. Note less foam cells in DKO macrophages compared with the KO macrophages. KO, ApoE KO mice; DKO, ApoE/CD36 DKO mice; V, vehicle.