Table 1.
Summary of structural and functional properties of the siglec family
| Siglec (other names) |
Murine ortholog or paralog |
Structure | Sialoside Preference* |
Cell type Expression** |
Disease relevance | Ref. | ||
|---|---|---|---|---|---|---|---|---|
| # Ig domains |
Tyrosine motifs |
DAP-12 Binding |
||||||
| Sialoadh esin (SAD, Sn, Siglec-1) |
Sialoadhesin (mSiglec-1, mSn) |
17 | None | No |  |
tissu macrophages (Activated monocytes) |
HIV-1 infection, Trypanosoma cruzi internalization |
11, 24, 71, 92- 94 |
| CD22 (Siglec-2) |
mCD22 (mSiglec-2) |
7 | ITIM ITIM-like Grb2 |
No |  |
B cells | Lymphoma, leukemia, SLE, Rheumatoid arthritis |
11, 47, 53, 55- 57, 95 |
| CD33 (Siglec-3) |
mCD33 (mSiglec-3) |
2 | ITIM ITIM-like |
Yes for mCD33? |
 |
Monocytes, basophils, CD34+ cells, dendritic cells, macrophages, mast cells, neutrophils (granulocytes, myeloid progenitors) |
Acute Myelogenouse Leukemia (AML) |
11, 37, 38, 93, 94, 96, 97 |
| MAG (Siglec-4) |
mMAG (mSiglec-4) |
5 | FYN- kinase site |
No |  |
oligodendrocytes, Schwann cells |
93, 94, 98 |
|
| Siglec-5 | - | 4 | ITIM ITIM-like |
No |  |
neutrophils, monocytes, basophils, CD34+ cells, macrophages, mast cells (B cells) |
Rheumatoid arthritis, N. maningitides infection |
11, 93, 97, 99 |
| Siglec-6 | - | 3 | ITIM ITIM-like |
No |  |
Basophils, mast cells, placental trophoblasts (B cells) |
11, 94, 100 |
|
| Siglec-7 | - | 3 | ITIM ITIM-like |
No |  |
NK cells, dendritic cells, monocytes, CD8+ T cells (monocytes) |
C. jejuni infection Cancer |
11, 40, 101 |
| Siglec-8 | Siglec-F | 3 | ITIM ITIM-like |
No |  |
eosinophils, mast cells (basophils) |
Eosinophilia, allergy | 11, 68 |
| Siglec-9 | - | 3 | ITIM ITIM-like |
No |  |
monocytes, neutrophils, dendritic cells, CD34+ cells, CD8+ T cells (NK cells) |
Rheumatoid arthritis |
11, 76, 97 |
| Siglec-10 | Siglec-G | 5 | ITIM ITIM-like Grb2 |
No |  |
B cells, CD34+ cells, dendritic cells, monocytes, NK cells (eosinophils) |
Lymphoma, leukemia, SLE, Rheumatoid arthritis, eosinophilia, allergy |
11, 93, 97, 102 |
| Siglec-11 | - | 5 | ITIM ITIM-like |
No |  |
Monocytes, macrophages, brain microglia |
103 | |
| Siglec-14 | - | 3 | None | Yes |  |
Not determined, but expected to be similar to Siglec-5 based on sequence homology |
99 | |
| Siglec-15 | mSiglec-15 | 2 | None | Yes |  |
macrophages, monocytes, dendritic cells |
104 | |
| Siglec-16 | - | 2 | None | Yes |  |
macrophages (brain microglia) |
10 | |
| - | Siglec-E | 3 | ITIM ITIM-like |
- |  |
neutrophils, monocytes, dendritic cells |
11 | |
| - | Siglec-H | 2 | None | Yes | plasmatoid dendritic cells (macrophages) |
11 | ||
Key: 
NeuAc 
NeuGc 
Gal 
GalNAc 
GlcNAc 
Fuc 
Sulfate
*
Sialoside preferences are taken from references cited, data from the Consortium for Functional Glycomics http://www.functionalglycomics.org, or inferred from the binding preferences of highly homologous siglecs. Carbohydrate sequences shown refer to preferences of the human counterparts, with the expection of Siglec-E.