Table 1.

Psychomotor activation in mice treated with the A_2A antagonist SCH442416

Genotype	Pretreatment	Treatment	n	Ambulatory activity		Fine movements
				% baseline at 15–30 min	% baseline at 30–45 min	% baseline at 15–30 min	% baseline at 30–45 min
WT	Vehicle	SCH442416	13	1849 ± 363*	1038 ± 226*	160 ± 14*	136 ± 13
WT	AM251	SCH442416	14	604 ± 158*#	421 ± 136*#	183 ± 24*	172 ± 25
CB1−/−	Vehicle	SCH442416	14	450 ± 52*#	290 ± 45*#	157 ± 17*	118 ± 14
WT	Vehicle	Vehicle	6	94 ± 16#	69 ± 16#	96 ± 2	105 ± 4
WT	AM251	Vehicle	6	88 ± 18#	41 ± 18*#	83 ± 15	84 ± 16

Data are mean ± SEM.

*p < 0.05 versus baseline.

^#p < 0.05 versus WT vehicle-pretreated SCH442416 mice.