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. Author manuscript; available in PMC: 2010 Mar 2.
Published in final edited form as: Gastroenterology. 2005 Aug;129(2):682–695. doi: 10.1016/j.gastro.2005.05.050

Figure 6.

Figure 6

Liver transforming growth factor (TGF)-β1 and phospho-Smad2 (p-Smad2) protein levels and correlation of liver ET-1 content with liver TGF-β1 or p-Smad2 levels in CBDL animals. Single bands of approximately 50 kilodaltons consistent with TGF-β1 (A) and 58 kilodaltons consistent with p-Smad2 or Smad2/3 (B) are seen. Graphs summarize TGF-β1 and p-Smad2 protein levels in liver. Values are expressed as means ± SE (n = 5–7 animals for each group). *P < .05 compared with normal controls. The relation is shown between ET-1 levels and TGF-β1or p-Smad2 levels in liver from control and CBDL animals (C). The linear correlation coefficient (r) was significant for each comparison. **P < .0001. A graphical summary is shown of TGF-β1 mRNA levels in cholangiocytes from control and 1-, 2-, and 3-week CBDL liver (D). Data are expressed relative to 18S levels as means ± SE and are from 4 to 5 real-time quantitative RT-PCR assays. P < .05 compared with normal control (n = 4–5 animals for each group).