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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Eur J Immunol. 2010 Jan;40(1):91–102. doi: 10.1002/eji.200939225

Figure 5. Evidence of natural processing for DRB3*0101 restricted epitopes.

Figure 5

A) Tetramer staining of DRB3*0101-TT36 specific CD4+ T cells following stimulation with whole tetanus toxin (1µg/ml), tetanus-diphtheria vaccine (0.4 UI of the adsorbed tetanus toxoid) or 10 µg/ml of TT-36 peptide. DRB3*0101-TT36 specific cells were observed for the three different stimuli, implying natural processing and presentation of the epitope. Reference staining of a DRB3*0101-TT36 specific CD4+ T cell line is also shown. B) Tetramer staining of DRB3*0101-TT102 specific CD4+ T cells following stimulation with whole tetanus toxin, tetanus-diphtheria vaccine, or peptide in the same manner as panel A. Reference staining of a DRB3*0101-TT102 specific CD4+ T cell line is also shown. TGEM with TT pools was performed in two individuals.