Figure 7.

L-Omp19 induces astrogliosis in the striatum of BALB/c mice. Mice received an intracranial injection of U-Omp19 (500 ng/ml), L-Omp19 (500 ng/ml), or vehicle solution (PBS). After 24 hours animals were sacrificed and striatum sections were subjected to immunostaining with anti-GFAP Ab (A) or with cresyl violet (B), and digital images close to or distant from the injection site were taken by confocal microscopy. Representative images revealed astrogliosis (A) and neutrophil infiltrate (B, arrows) in animals treated with L-Omp19, but not in U-Omp19 (500 ng/ml) or PBS-treated ones. Scale bar = 50 μm.