Table 1.

Mean data for wild-type and mutant K_ATP channels.

	IC50	IC50	Fractional current in 3 mm MgATP	Po(0)
	Mg2+-free	Mg2+	Mg2+
WT	10 ± 1 (n = 13)	16 ± 1 (n = 18)	1.0 ± 0.1 (n = 18)	0.29 ± 0.02 (n = 25)
homF60Y	378 ± 82 (n = 7)**	1781 ± 321 (n = 8)***	54 ± 7 (n = 8)***	0.86 ± 0.01 (n = 26)***
hetF60Y	93 ± 27 (n = 7)*	188 ± 35 (n = 9)**	21 ± 3 (n = 9)***
homV64L	14 ± 1 (n = 7)**	36 ± 5 (n = 9)**	5 ± 1 (n = 9)*	0.41 ± 0.02 (n = 19)***
hetV64L	13 ± 2 (n = 8)*	27 ± 4 (n = 8)*	2 ± 1 (n = 8)
F60Y + V64L	160 ± 42 (n = 8)**	189 ± 25 (n = 15)***	19 ± 3 (n = 15)***
homF60Y/V64L	233 ± 80 (n = 9)*	316 ± 47 (n = 12)***	34 ± 3 (n = 12)***	0.79 ± 0.02 (n = 22)***
hetF60Y/V64L	30 ± 6 (n = 7)*	97 ± 22 (n = 11)**	14 ± 2 (n = 11)***

Data are mean ± SEM (n = number of patches).

*P ≤ 0.05 against wild-type (Student's t-test).

**P ≤ 0.01 (Student's t-test).

***P ≤ 0.001 (Student's t-test).