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AIPL1 is needed for the cone photoreceptor light response. Full-field light-adapted ERG recordings in P15 (A) and P30 (B) show a typical cone electrical response in tg hAipl1; Aipl1+/− mice. Tg hAipl1; Aipl1−/− mice have no light-derived cone electrical response, similar to Aipl1−/−. ERGs were recorded at 2.5 cd s m−2 in the presence of a 30 cd m−2 background light. These recordings are an average of at least three different mice. Littermates were used to compare responses.
