Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Dec 30;19(6):1076–1087. doi: 10.1093/hmg/ddp571

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

PMC Copyright notice

Figure 5. — Cone degeneration is slow in the presence of rescued rod photoreceptors. Whole-mounted retinas from P18 Aipl1^+/+ (A), Aipl1^−/− (B), tg hAipl1; Aipl1^−/− (T−/−) (C) and adult (P40) tg hAipl1; Aipl1^−/− (D) were labeled with anti-S- and M-opsin antibodies. Images were taken from the dorsal (D) and ventral (V) regions of the retina. Aipl1^+/+ retina (A) shows typical distribution of S-opsin containing cones in the ventral retina (A3) and M-opsin containing cones throughout the dorsal and ventral retina (A2 and A4). The majority of cone photoreceptors degenerate by P18 in Aipl1^−/− mice (B) except for a few remaining M-cones in the dorsal retina (B2). However, in tg hAipl1; Aipl1^−/− retina, there was no obvious reduction in the number of cones and the cone distribution was similar to that of wild-type at P18 (C). These cones degenerate slowly and at P40 a drastic reduction in cone photoreceptor number was observed in tg hAipl1; Aipl1^−/− retina (D). Images were taken at ×40 magnification.