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. 2009 Oct 16;9(2):197–208. doi: 10.1074/mcp.M900152-MCP200

Fig. 3.

Fig. 3.

Protein domain distribution of LIM1215-derived pure exosomal proteins and overlap of urine-, mast cell-, and LIM1215-derived pure exosomal proteomes. A, distribution of protein domains that are preferentially enriched in the LIM1215-derived pure exosomes. Coiled coil domain is predicted to be present in ∼23% of the exosomal proteome, whereas it is present in only ∼11% of the entire human proteome (human RefSeq proteome). Likewise, RAS and MIRO domains are highly significant in the LIM1215-derived pure exosomal proteomes (11%) as compared with the entire human proteome (0.7%). B, three-way Venn diagram depicting the overlap between the exosomal proteomes derived from urine, mast cells, and LIM1215 cells. Here, two previous exosomal studies published in the scientific literature were used to find the overlap between the exosomal proteomes. 31 proteins were found to be identified in all three exosomal proteomes, whereas 96 and 79 proteins were found to be in common between LIM1215-urine and LIM1215-mast cell exosome data sets, respectively.