Table 3.
HRs and 95% CIs for Lipid Parameters and Risk of Ischemic Stroke Using Dichotomous Definitions
| Lipid Parameter | Unadjusted HR (95% CI) | Adjusted HR (95% CI)a |
|---|---|---|
| HDL-C level (men, <40 mg/dL; women, <50 mg/dL) | 1.14 (0.84–1.55) | 1.21 (0.87–1.69) |
| LDL-C level > 130 mg/dL | 0.68 (0.49–0.93) | 0.71 (0.51–0.98) |
| Taking cholesterol-lowering medicationb | 0.40 (0.23–0.72) | |
| Not taking cholesterol-lowering medicationb | 1.09 (0.73–1.62) | |
| TG level > 200 mg/dL | 1.4 (0.94–2.08) | 1.19 (0.77–1.84) |
| TG:HDL-C ratio > 2 | 1.03 (0.75–1.43) | 0.88 (0.62–1.26) |
| Non–HDL-C level > 160 mg/dL | 0.75 (0.55–1.03) | 0.74 (0.53–1.02) |
| Taking cholesterol-lowering medicationb | 0.48 (0.27–0.84) | |
| Not taking cholesterol-lowering medicationb | 1.15 (0.77–1.73) | |
| Total cholesterol level > 240 mg/dL | 0.82 (0.54–1.25) | 0.76 (0.48–1.18) |
| Taking cholesterol-lowering medicationb | 0.52 (0.25–1.08) | |
| Not taking cholesterol-lowering medicationb | 1.38 (0.78–2.45) | |
| Total cholesterol:HDL-C ratio in the upper quartile | 0.97 (0.69–1.39) | 0.79 (0.54–1.16) |
Abbreviations: CI, confidence interval; HDL-C, high-density lipoprotein cholesterol; HR, hazard ratio; LDL-C, low-density lipoprotein cholesterol; TG, triglycerides.
SI conversion factors: See Table 2.
a
Adjusted for age, sex, race/ethnicity, education, hypertension, diabetes mellitus, other lipid profile parameters, smoking, coronary artery disease, moderate alcohol consumption, and physical activity.
b
Stratified models based on an interaction term with lipid-lowering medications, P <.05.