Table 2.
Univariable Analyses of Progression to ESRD
| ESRD at 1 Year |
ESRD During Total Follow-up |
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (/1 SD) | 1.32 | 0.97-1.78 | 0.07 | 1.15 | 0.92-1.45 | 0.2 |
| Initial SCr (/1 mg/dL) | 1.26 | 1.19-1.33 | <0.001 | 1.24 | 1.18-1.29 | <0.001 |
| % Normal glomeruli (/1 SD) | 0.27 | 0.15-0.49 | <0.001 | 0.34 | 0.23-0.49 | <0.001 |
| % Active glomeruli (/1 SD) | 1.59 | 1.24-2.07 | 0.001 | 1.47 | 1.20-1.82 | <0.001 |
| % Sclerosed glomeruli (/1 SD) | 1.46 | 1.13-1.88 | 0.003 | 1.54 | 1.27-1.87 | <0.001 |
| Index of chronic damage (/1 SD) | 1.72 | 1.32-2.24 | <0.001 | 1.78 | 1.42-2.22 | <0.001 |
Note: SCr is treated as a continuous variable; other variables are divided into groups by 1 SD, which corresponds to 16 years for age, 33% for percentage of normal glomeruli, 30% for percentage of active glomeruli, 21% for percentage of sclerosed glomeruli, and 30% for index of chronic damage.
Abbreviations: CI, confidence interval; ESRD, end-stage renal disease; HR, hazard ratio; SCr, serum creatinine; SD, standard deviation.