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. Author manuscript; available in PMC: 2010 Mar 2.
Published in final edited form as: Int J Pharm. 2008 Jun 27;362(1-2):93–101. doi: 10.1016/j.ijpharm.2008.06.018

Table 4.

Pharmacokinetic Parameters for systemic absorption of amino acid prodrugs of ACV. Values presented herewith are for total concentration.

Parameter ACV AACV SACV IACV EACV VACV
λz (T) (1/min) 0.04 ± 0.006 0.04 ± 0.004 0.01± 0.002 0.01 ± 0.002 0.01 ± 0.0003 0.02 ± 0.002
Tmax (T) (min) 19 ± 4 20 ± 8.6 14 ± 5 34 ± 4 80 ± 9 20 ± 4.3
Cmax (T) (µM) 2.3 ± 0.3 12.1 ± 1.8 39 ± 2 20 ± 5 2.5 ± 0.1 22 ± 0.3
Clast (T) (µM) 0.06 ± 0.04 0.03 ± 0.01 0.18 ± 0.06 0.2 ± 0.01 0.2 ± 0.02 0.12 ± 0.008
AUCinf (T) (min*µM) 204 ± 33 524 ± 28 1466 ± 173 815 ± 104 345 ± 40 1032 ± 130
MRTlast (T) (min) 72 ± 6.4 47 ± 3 51 ± 10 64 ± 2 115 ± 5 49 ± 2

Values are mean ± S.E. (n=4–6)

a control

*

p<0.05 compared to control.

T- total concentration in terms of ACV; MRT- mean residence time, AUC- area under curve, Cmax- maximum concentration, Tmax- time to reach maximum concentration, λZ- terminal elimination rate constant, Clast- concentration at the last time point.