Table 2. Genes most frequently published in AML expression studies.

Rank	Gene symbol	No. of references	No. of platforms	No. of differentially expressed features	Gene name
1	HOXB2	12	6	32	homeobox B2
2	PBX3	12	5	31	pre-B-cell leukemia homeobox 3
3	HOXA9	11	4	35	homeobox A9
4	POU4F1	11	3	29	POU class 4 homeobox 1
5	TSPAN7	10	5	16	tetraspanin 7
6	MYH11	10	3	38	myosin, heavy chain 11, smooth muscle
7	RUNX1T1	10	3	34	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
8	TRH	10	3	21	thyrotropin-releasing hormone
9	HLA-DPA1	10	3	20	major histocompatibility complex, class II, DP alpha 1
10	HOXB5	9	5	32	homeobox B5
11	SPARC	9	5	16	secreted protein, acidic, cysteine-rich (osteonectin)
12	HOXA10	9	4	34	homeobox A10
13	RNASE2	9	4	18	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
14	CD34	9	3	16	CD34 molecule
15	MEIS1	9	3	16	Meis homeobox 1
16	RUNX3	8	5	23	runt-related transcription factor 3
17	VCAN	8	5	22	versican proteoglycan
18	RBPMS	8	4	21	RNA binding protein with multiple splicing
19	HOXA4	8	4	18	homeobox A4
20	MN1	8	4	16	meningioma (disrupted in balanced translocation) 1
21	PRAME	8	4	11	preferentially expressed antigen in melanoma
22	JAG1	8	3	20	jagged 1 (Alagille syndrome)
23	ITM2A	8	3	18	integral membrane protein 2A
24	RGS10	8	3	17	regulator of G-protein signaling 10
25	PGDS *	8	2	12	prostaglandin D2 synthase, hematopoietic

The genes reported in at least eight independent studies are presented here. In order of preference, the genes are ranked by the number of independent studies, the number of unique platforms, and the total number of differentially expressed features.

*Gene symbol is not approved by HUGO Gene Nomenclature Committee.