Table 3. Number of genes and independent publications with selected prognostic categories.
Tag (total genes) (total references) | No. genes in 1 study | No. genes in 2 studies | No. genes in 3 studies | No. genes in 4 studies | No. genes in 5 studies | No. genes in 6 studies | No. genes in 7 studies | No. genes in 8 studies | |
poor prog (1727) (12) | all genes | 1559 | 138 | 27 | 3 | ||||
up-regulated | 586 | 28 | 2 | ||||||
down-regulated | 943 | 55 | 10 | 1 | |||||
good prog (1638) (11) | all genes | 1484 | 134 | 18 | 1 | 1 | |||
up-regulated | 925 | 62 | 9 | 1 | |||||
down-regulated | 528 | 24 | 2 | ||||||
NPM1 mut (1169) (5) | all genes | 978 | 147 | 32 | 11 | 1 | |||
up-regulated | 541 | 42 | 18 | 7 | 1 | ||||
down-regulated | 436 | 96 | 13 | 2 | |||||
t(15;17) (230) (9) | all genes | 188 | 25 | 9 | 7 | 1 | |||
up-regulated | 115 | 17 | 5 | 6 | |||||
down-regulated | 56 | 8 | 4 | 1 | 1 | ||||
inv(16) (1322) (9) | all genes | 1197 | 88 | 23 | 7 | 6 | 1 | ||
up-regulated | 533 | 44 | 12 | 7 | 2 | 1 | |||
down-regulated | 285 | 15 | 4 | 1 | |||||
t(8;21) (1195) (9) | all genes | 1057 | 92 | 23 | 15 | 4 | 1 | 2 | 1 |
up-regulated | 253 | 32 | 13 | 4 | 1 | 2 | 1 | ||
down-regulated | 552 | 27 | 5 | 2 | |||||
11q23 (482) (5) | all genes | 459 | 19 | 4 | |||||
up-regulated | 65 | 1 | |||||||
down-regulated | 45 | 3 | |||||||
FLT3-ITD (235) (4) | all genes | 224 | 10 | 1 | |||||
up-regulated | 135 | 2 | |||||||
down-regulated | 67 | ||||||||
normal cyto (519) (6) | all genes | 480 | 36 | 3 | |||||
up-regulated | 173 | 1 | |||||||
down-regulated | 206 | 6 |
The AML prognosis and subtype identification tags reported in greater than 3 independent studies are shown with the number of genes listed by number of independent studies and differential expression direction. Identification tag descriptions can be found in Table S1. Note that the following tags are abbreviated: poor prog is poor prognosis, good prog is good prognosis, NPM1 mut is NPM1 mutation, and normal cyto is normal cytogenetics.